Selected Publications
Ze-Yan Zhang, Yingwen Ding, Ravesanker Ezhilarasan, Tenzin Lhakhang, Qianghu Wang, Jie Yang, Modrek AS, Hua Zhang, Aristotelis Tsirigos, Andrew Futreal, Giulio F. Draetta, Roel G.W. Verhaak, Erik P. Sulman. Lineage-coupled Clonal Capture Identifies Clonal Evolution Mechanisms and Vulnerabilities of BRAF V600E Inhibition Resistance in Melanoma. Cell Discovery. 2022.
Modrek AS, Eskilsson E, Ezhilarasan R, Wang Q, Goodman LD, Ding Y, Zhang ZY, Bhat K, Le T, Barthel FP, Tang M, Yang J, Long L, Gumin J, Lang F, Verhaak R, Aldape K, Sulman EP. PDPN marks a subset of tumor initiating and radiation resistant glioblastoma cells. Frontiers in Oncology. 2022.
Modrek AS, Tanese N, Placantonakis DG, Sulman EP, Rivera Jr R, Du KL, Gerber NK, David G, Chesler M, Philips MR and Cangiarella J. Breaking Tradition to Bridge Bench and Bedside: Accelerating the MD-PhD-Residency Pathway. Academic Medicine. 2021.
Danielle Golub, Nishanth Iyengar, Siddhant Dogra, Taylor Wong, Devin Bready, Karen Tang, Modrek AS, Dimitris G Placantonakis. Mutant Isocitrate Dehydrogenase Inhibitors as Targeted Cancer Therapeutics. Frontiers in Oncology. 2019.
Stafford JM, Lee CH, Voigt P, Descostes N, Saldaña-Meyer R, Yu JR, Leroy G, Oksuz O, Chapman JR, Suarez F, Modrek AS, Bayin NS, Placantonakis DG, Karajannis MA, Snuderl M, Ueberheide B and Reinberg D. Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma. Science Advances. 2018.
Modrek AS, Golub D, Khan T, Prado J, Bowman C, Deng J, Zhang G, Rocha PP, Raviram R, Lazaris HC, Stafford J, LeRoy G, Kader M, Dhaliwal J, Bayin NS, Frenster J, Serrano J, Chiriboga L, Baitalmal R, Nanjangud G, Chi AS, Golfinos JG, Wang J, Karajannis M, Bonneau RA, Reinberg D, Tsirigos A, Zagzag D, Snuderl M, Skok JA, Neubert T, and Placantonakis DG. Astrocytoma mutations IDH1, p53 and ATRX cooperate to block differentiation of neural stem cells via epigenetic silencing of SOX2. Cell Reports. 2017.
Bayin NS, Frenster JD, Sen R, Si S, Modrek AS, Ortenzi V, Zagzag D, Snuderl M, Golfinos JG, Doyle W, Galifianakis N, Chesler M, Illa-Bochaca I, Barcellos-Hoff MH, Dolgalev I, Heguy A and Placantonakis DG. Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells. Oncotarget. 2017.
Bayin NS, Frenster JD, Kane J, Rubenstein J, Modrek AS, Baitalmal R, Dolgalev I, Rudzenski K, Snuderl M, Golfinos JG, Doyle W, Pacione D, Parker EC, Chi AS, Heguy A, MacNeil DJ, Shohdy N, Zagzag D and Placantonakis DG. GPR133, an adhesion G protein-coupled receptor, is necessary for glioblastoma growth. Oncogenesis. 2016.
Bayin NS, Modrek AS, Dietrich A, Lebowitz J, Abel T, Song H, Schober M, Zagzag D, Buchholz C, Chao M and Placantonakis DG. Selective Lentiviral Gene Delivery to CD133-Expressing Human Glioblastoma Stem Cells. PLoS One. 2014.
Wang DDH, Guo XE, Modrek AS, Chen PL and Lee WH. SUV3/PNPase/mtPAP modulates mitochondrial mRNA poly(A) tail length in response to energetic changes. The Journal of Biological Chemistry. 2014.
Bayin NS, Modrek AS and Placantonakis DG. Glioma cancer stem cells. World Journal of Stem Cells. 2014.
Modrek AS, Bayin NS and Placantonakis DG. Brain stem cells as the cell of origin in glioma. World Journal of Stem Cells. 2014.
Guo XE, Ngo B, Modrek AS and Lee WH. Targeting Loss of Tumor Suppressors for Cancer Therapeutics. Current Drug Targets. 2014.
Guo XE, Chen CF, Wang DDH, Modrek AS, Phan V, Lee WH and Chen PL. Uncoupling the Role of SUV3 in maintenance of Mitochondrial Genome Stability and RNA Degradation. The Journal of Biological Chemistry. 2011.